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KMID : 1134820080370020177
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Journal of the Korean Society of Food Science and Nutrition
2008 Volume.37 No. 2 p.177 ~ p.183
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Hepatoprotective Activity of Dandelion (Taraxacum officinale) Water Extract against D-Galactosamine-Induced Hepatitis in Rats
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Park Ji-Young
Park Chung-Mu
Kim Jin-Ju
Song Young-Sun
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Abstract
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This study aimed to investigate the protective effect of dandelion water extract (DWE) on liver injury induced by D-galactosamine (GalN) in Sprague-Dawley rats. Fifty rats were divided into 5 groups; normal control (C), DWE-control (DWE-C: saline injection after feeding 3% DWE diet), GalN-control (GalN-C: GalN injection after normal diet), DWE Ⅰ (GalN injection after feeding 1.5% DWE diet), and DWE Ⅱ (GalN injection after feeding 3% DWE diet). After 2 weeks, the acute hepatitis was induced by GalN (650 mg/kg, i.p.) and 24 hrs later, all rats were sacrificed. The DWE supplement ameliorated the serum alanine and aspartate aminotransferase (AST, ALT) as well as alkaline phosphatase (ALP) and tumor necrosis factor-α (TNF-α). Hepatic antioxidative enzyme activities, such as catalase, GSH peroxidase, GSH reductase, and Mn-superoxide dismutase (SOD) were slightly or significantly elevated by the treatment of DWE. Moreover, the histological examination corresponded with these biochemical observations. According to these findings, dandelion could be used as a potential therapeutic material for treating chemically induced acute hepatitis.
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KEYWORD
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dandelion water extract , D-galactosamine , hepatitis , antioxidative enzymes
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